Characters who are able to transmutate a target, allowing them to transform something into something else.
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- Daleks
- Darkseid
- Delsin Rowe
- Demigra
- Discord (IDW Comics)
- Doctor Doom
- Doctor Ivo Robotnik (Adventures of Sonic the Hedgehog)
- Doctor Ivo Robotnik (Sonic the Comic)
- Doctor Manhattan
- Doctor Strange (Marvel Cinematic Universe)
- Dogscape
- Donquixote Doflamingo
- Dormammu
- Dorothy Gale
- Dr. Crawler
- Dr. Maniac
- Dragon (D&D)
- Durin's Bane
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- Thanos
- Thanos (Marvel Cinematic Universe)
- The Angry Video Game Nerd
- The Body Squeezers
- The Celestial Toymaker
- The Chosen Undead
- The Clock of Doom
- The Doctor
- The Emperor of Mankind
- The Evil Camera
- The Evil Knight
- The Horde
- The Hunter (Bloodborne)
- The Joker (Post-Crisis)
- The Lord High Executioner
- The Mask (Live-Action Movie)
- The Masked Mutant
- The Menace
- The Player (Catalog Heaven)
- The Poltergeists
- The Princess (Creepypasta)
- The Sentry
- The Spectre
- The Truth (Fullmetal Alchemist)
- Thor (Marvel Comics)
- Trixie Lulamoon
- Troy Burrows
- Twilight Sparkle
- Twilight Sparkle (IDW Comics)
- Twisted Unicorn
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